Glossary of FDA Approved Drugs for Melanoma

Glossary of FDA approved drugs for Advanced Melanoma

*Please note, this list does not include all drugs used to treat melanoma skin cancer. Your doctor will help find the best treatment for your tumor.
Generic nameTrade nameLink to prescribing information
AtezolizumabTecentriq®https://www.tecentriq.com/melanoma.html
BinimetinibMektovi®https://www.braftovimektovi.com/
CobimetinibCotellic®https://www.cotellic.com/
DabrafenibTafinlar®https://www.us.tafinlarmekinist.com/
EncorafenibBraftovi®https://www.braftovimektovi.com/
Entrectinib*RozlytrekTMhttps://www.rozlytrek.com/
Interleukin-2Proleukin® (Aldesleukin)https://proleukin.com/
IpilimumabYervoy®https://www.yervoy.com/
Larotectinib*Vitrakvi®https://hcp.vitrakvi-us.com/
NivolumabOpdivo®https://www.opdivo.com/
Nivolumab plus RelatlimabOpdualagTMhttps://www.opdualag.com/
PembrolizumabKeytruda®https://www.keytruda.com/melanoma/
Talimogene laherparepvecImlygic®https://www.imlygic.com/
TrametinibMekinist®https://www.us.tafinlarmekinist.com/
VemurafenibZelboraf®https://www.gene.com/patients/medicines/zelboraf
Generic NameBrand NameType of DrugRouteLink to Website
AtezolizumabTecentriqImmunotherapy Immune checkpoint inhibitor (anti-PD-L1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.tecentriq.com/
Atezolizumab/hyaluronidase-tqjsTecentriq HybrezaImmunotherapy Immune checkpoint inhibitor (anti-PD-L1)https://activate-melanoma.com/wp-content/uploads/2025/05/syringe.pnghttps://www.tecentriq.com/hybreza.html
BinimetinibMektoviTargeted therapy (anti-MEK) Used with encorafenibhttps://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.braftovi.com/
CobimetinibCotellicTargeted therapy (anti-MEK) Used with vemurafenib
https://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.gene.com/patients/medicines/cotellic
DabrafenibTafinlarTargeted therapy (anti-BRAF) Used with trametinibhttps://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://us.tafinlarmekinist.com/advanced-melanoma
DacarbazineDTIC-DomeChemotherapyhttps://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://medlineplus.gov/druginfo/meds/a682750.html
EncorafenibBraftoviTargeted therapy (anti-BRAF) Used with binimetinibhttps://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.braftovi.com/https://www.braftovi.com/
Interleukin-2 (IL-2, aldesleukin)ProleukinImmunotherapyhttps://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.proleukin.com/
IpilimumabYervoyImmunotherapy Immune checkpoint inhibitor (anti-CTLA-4)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://packageinserts.bms.com/medguide/medguide_yervoy.pdf?
LifileucelAmtagviImmunotherapy T-cell therapy
https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.amtagvi.com/
NivolumabOpdivoImmunotherapy Immune checkpoint inhibitor (anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.opdivo.com/
Nivolumab + hyaluronidase-nhvyOpdivo QvantigImmunotherapy Immune checkpoint inhibitor (anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/syringe.pnghttps://www.opdivohcp.com/efficacy/subcutaneous-administration
PembrolizumabKeytrudaImmunotherapy Immune checkpoint inhibitor (anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.keytruda.com/
Relatlimab + nivolumabOpdualagImmunotherapy Immune checkpoint inhibitor (anti-LAG-3 + anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.png https://www.opdualag.com/
Talimogene Laherparapvec (T-VEC)ImlygicViral therapyhttps://activate-melanoma.com/wp-content/uploads/2025/05/syringe.pnghttps://www.imlygic.com/
TrametinibMekinistTargeted therapy (anti-MEK) Used with dabrafenib)https://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://us.tafinlarmekinist.com/
VemurafenibZelborafTargeted therapy (anti-BRAF)https://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.gene.com/patients/medicines/zelboraf

*for metastatic melanoma with an NTRK fusion (mutation)

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