Glossary of FDA Approved Drugs for Melanoma

Glossary of FDA approved drugs for Advanced Melanoma

*Please note, this list does not include all drugs used to treat melanoma skin cancer. Your doctor will help find the best treatment for your tumor.
Generic nameTrade nameLink to prescribing information
AtezolizumabTecentriq®https://www.tecentriq.com/melanoma.html
BinimetinibMektovi®https://www.braftovimektovi.com/
CobimetinibCotellic®https://www.cotellic.com/
DabrafenibTafinlar®https://www.us.tafinlarmekinist.com/
EncorafenibBraftovi®https://www.braftovimektovi.com/
Entrectinib*RozlytrekTMhttps://www.rozlytrek.com/
Interleukin-2Proleukin® (Aldesleukin)https://proleukin.com/
IpilimumabYervoy®https://www.yervoy.com/
Larotectinib*Vitrakvi®https://hcp.vitrakvi-us.com/
NivolumabOpdivo®https://www.opdivo.com/
Nivolumab plus RelatlimabOpdualagTMhttps://www.opdualag.com/
PembrolizumabKeytruda®https://www.keytruda.com/melanoma/
Talimogene laherparepvecImlygic®https://www.imlygic.com/
TrametinibMekinist®https://www.us.tafinlarmekinist.com/
VemurafenibZelboraf®https://www.gene.com/patients/medicines/zelboraf
Generic NameBrand NameType of DrugRouteLink to Website
AtezolizumabTecentriq® Immunotherapy Immune checkpoint inhibitor (anti-PD-L1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.tecentriq.com/
Atezolizumab/
hyaluronidase-tqjs
Tecentriq HybrezaImmunotherapy Immune checkpoint inhibitor (anti-PD-L1)https://activate-melanoma.com/wp-content/uploads/2025/05/syringe.pnghttps://www.tecentriq.com/hybreza.html
BinimetinibMektovi® Targeted therapy (anti-MEK) Used with encorafenibhttps://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.braftovi.com/
CobimetinibCotellic® Targeted therapy (anti-MEK) Used with vemurafenib
https://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.gene.com/patients/medicines/cotellic
DabrafenibTafinlar® Targeted therapy (anti-BRAF) Used with trametinibhttps://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://us.tafinlarmekinist.com/advanced-melanoma
DacarbazineDTIC-Dome® Chemotherapyhttps://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://medlineplus.gov/druginfo/meds/a682750.html
EncorafenibBraftovi® Targeted therapy (anti-BRAF) Used with binimetinibhttps://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.braftovi.com/https://www.braftovi.com/
Interleukin-2 (IL-2, aldesleukin)Proleukin® Immunotherapyhttps://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.proleukin.com/
IpilimumabYervoy® Immunotherapy Immune checkpoint inhibitor (anti-CTLA-4)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://packageinserts.bms.com/medguide/medguide_yervoy.pdf?
LifileucelAmtagvi® Immunotherapy T-cell therapy
https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.amtagvi.com/
NivolumabOpdivo® Immunotherapy Immune checkpoint inhibitor (anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.opdivo.com/
Nivolumab +
hyaluronidase-nhvy
Opdivo QvantigImmunotherapy Immune checkpoint inhibitor (anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/syringe.pnghttps://www.opdivohcp.com/efficacy/subcutaneous-administration
PembrolizumabKeytruda® Immunotherapy Immune checkpoint inhibitor (anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.pnghttps://www.keytruda.com/
Relatlimab +
nivolumab
Opdualag® Immunotherapy Immune checkpoint inhibitor (anti-LAG-3 + anti-PD-1)https://activate-melanoma.com/wp-content/uploads/2025/05/blood-bag.png https://www.opdualag.com/
Talimogene
Laherparapvec (T-VEC)
Imlygic® Viral therapyhttps://activate-melanoma.com/wp-content/uploads/2025/05/syringe.pnghttps://www.imlygic.com/
TrametinibMekinist® Targeted therapy (anti-MEK)
Used with dabrafenib)
https://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://us.tafinlarmekinist.com/
VemurafenibZelboraf® Targeted therapy (anti-BRAF)https://activate-melanoma.com/wp-content/uploads/2025/05/tablets.pnghttps://www.gene.com/patients/medicines/zelboraf

Date of last review: September 9, 2025

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